Methylenetetrahydrofolate Reductase C677T Polymorphism and Cognitive Function in Older Women
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چکیده
منابع مشابه
Methylenetetrahydrofolate reductase C677T polymorphism and cognitive function in older women.
Homocysteine may play a causal role in cognitive decline. The authors analyzed the 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T genotype, a correlate of plasma homocysteine levels, among 6,653 participants in the Study of Osteoporotic Fractures, a community-based, prospective cohort study of older women in four US states. During the years 1986-1998, the authors assessed whether the di...
متن کاملOriginal Contribution Methylenetetrahydrofolate Reductase C677T Polymorphism and Cognitive Function in Older Women
1 Department of Neurology, School of Medicine, University of California, San Francisco, San Francisco, CA. 2 Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, San Francisco, CA. 3 Department of Medicine, School of Medicine, University of California, San Francisco, San Francisco, CA. 4 Department of Medicine, David Geffen School of Medicin...
متن کاملEvaluation of the Association between the C677T Polymorphism of Methylenetetrahydrofolate Reductase Gene and Recurrent Spontaneous Abortion
Introduction: One factor known to cause thrombophilia in women with unexplained recurrent spontaneous abortion (RSA) is C677T polymorphism of methylenetetrahydrofolate reductase gene. This study aimed to determine the association between RSA and MTHFR C677T polymorphism in Iranian patients. Methods: In this case-control study, 30 patients with previous history of two or more consecutive unexpla...
متن کاملMethylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in psoriasis in southern Turkey*
Background: Psoriasis is a multigenic and multifactorial dermatological disease linked to cardiovascular diseases. Increased levels of homocysteine in patients with psoriasis have been demonstrated in many studies. The most frequently investigated genetic defect that plays a role in homocysteine metabolism is single point substitution (C to T) located on the 677th nucleotide of the methylenetet...
متن کاملMethylenetetrahydrofolate Reductase C677T and A1298C Polymorphism in Iranian Women With Idiopathic Recurrent Pregnancy Losses
BACKGROUND Recurrent pregnancy loss (RPL) is a serious problem for pregnancy. There is evidence that vascular complications play a principal role in RPL. Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. Polymorphisms (C677T, A1298C) of MTHFR gene are associated with decreased MTHFR activity. OBJECTIVES The aim of this study was to determine the association bet...
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ژورنال
عنوان ژورنال: American Journal of Epidemiology
سال: 2007
ISSN: 0002-9262,1476-6256
DOI: 10.1093/aje/kwm140